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apalutamide will minimize the level or result of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications which might be CYP3A4 substrates can result in lessen publicity to these prescription drugs.bosentan will decrease the level or o